Name		Synonyms
Generalized seizures		Generalized seizures recurrent Infrequent generalized seizures Seizures generalized afebrile

Primary ID		Alternative IDs
HP:0002197		HP:0002409 HP:0007114 HP:0007339

Term definition
Seizures of with initial involvement of both cerebral hemispheres.

Super-classes (vis)		Sub-classes (vis)
Seizures		Generalized tonic-clonic seizures ; Generalized myoclonic seizures ; Absence seizures ; Atonic seizures ; Generalized tonic seizures ; Generalized clonic seizures

Diseases / genes associated with this term

Disease		Gene(s)
ALTERNATING HEMIPLEGIA OF CHILDHOOD		ATP1A2
CENTRALOPATHIC EPILEPSY
#121200 SEIZURES, BENIGN FAMILIAL NEONATAL, 1; BFNS1EPILEPSY, BENIGN NEONATAL, 1, AND/OR MYOKYMIA, INCLUDED;;SEIZURES, BENIGN FAMILIAL NEONATAL, 1, AND/OR MYOKYMIA, INCLUDED		KCNQ2
#121201 SEIZURES, BENIGN FAMILIAL NEONATAL, 2; BFNS2;;CONVULSIONS, BENIGN FAMILIAL NEONATAL, 2; BFNC2		KCNQ3
%121210 FEBRILE SEIZURES, FAMILIAL, 1; FEB1;;CONVULSIONS, FAMILIAL FEBRILE; 1		FEB1
MYOCLONIC EPILEPSY, HARTUNG TYPE
MYOCLONUS, HEREDITARY, WITH PROGRESSIVE DISTAL MUSCULAR ATROPHY		ASAH1
PELGER-HUET ANOMALY		LBR
172500 PHOTOMYOCLONUS, DIABETES MELLITUS, DEAFNESS, NEPHROPATHY, AND CEREBRALDYSFUNCTION;;HERRMANN SYNDROME
ATAXIA WITH MYOCLONIC EPILEPSY AND PRESENILE DEMENTIA
ATHEROSCLEROSIS, PREMATURE, WITH DEAFNESS, NEPHROPATHY, DIABETES MELLITUS,PHOTOMYOCLONUS, AND DEGENERATIVE NEUROLOGIC DISEASE
CARNOSINEMIA
DEAFNESS, CONGENITAL, AND FAMILIAL MYOCLONIC EPILEPSY
EPILEPSY, PHOTOGENIC, WITH SPASTIC DIPLEGIA AND MENTAL RETARDATION
GM1-GANGLIOSIDOSIS, TYPE II		GLB1
#231000 GAUCHER DISEASE, TYPE III;;GD III;;GAUCHER DISEASE, SUBACUTE NEURONOPATHIC TYPE;;GAUCHER DISEASE, CHRONIC NEURONOPATHIC TYPE;;GAUCHER DISEASE, JUVENILE AND ADULT, CEREBRALGAUCHER DISEASE, TYPE IIIA, INCLUDED;;GAUCHER DISEASE, TYPE IIIB, INCLUDED;;GAUCHER DISEASE, NORRBOTTNIAN TYPE, INCLUDED		GBA
%234100 HALLERMANN-STREIFF SYNDROME; HSS;;FRANCOIS DYSCEPHALIC SYNDROME		GJA1
HISTIDINURIA DUE TO A RENAL TUBULAR DEFECT
HYDROXYLYSINURIA
#238970 HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA SYNDROME;;HHH SYNDROME; HHHS; HHH;;ORNITHINE TRANSLOCASE DEFICIENCY		SLC25A15
MERCAPTOLACTATE-CYSTEINE DISULFIDURIA
251280 MICROCEPHALY WITH SPASTIC QUADRIPLEGIA
#254770 EPILEPSY, MYOCLONIC JUVENILE; EJM;;MYOCLONIC EPILEPSY, JUVENILE; JME;;PETIT MAL, IMPULSIVE;;JANZ SYNDROMEMYOCLONIC EPILEPSY, JUVENILE, SUSCEPTIBILITY TO, 1, INCLUDED; EJM1,INCLUDED
MYOCLONIC EPILEPSY OF LAFORA		EPM2A ; NHLRC1
MYOCLONIC EPILEPSY OF UNVERRICHT AND LUNDBORG		CSTB
ACTION MYOCLONUS-RENAL FAILURE SYNDROME		SCARB2
#257300 MOSAIC VARIEGATED ANEUPLOIDY SYNDROME 1; MVA1;;MVA SYNDROME		BUB1B
#266100 EPILEPSY, PYRIDOXINE-DEPENDENT; EPD;;PYRIDOXINE-DEPENDENT EPILEPSY; PDE;;PYRIDOXINE DEPENDENCY WITH SEIZURES;;AASA DEHYDROGENASE DEFICIENCY		ALDH7A1
EPILEPSY, BENIGN NEONATAL, AUTOSOMAL RECESSIVE
#271900 CANAVAN DISEASE;;CANAVAN-VAN BOGAERT-BERTRAND DISEASE;;SPONGY DEGENERATION OF CENTRAL NERVOUS SYSTEM;;ASPARTOACYLASE DEFICIENCY;;ASPA DEFICIENCY;;ASP DEFICIENCY;;AMINOACYLASE 2 DEFICIENCY;;ACY2 DEFICIENCY		ASPA
#271980 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY;;SSADH DEFICIENCY;;4-@HYDROXYBUTYRIC ACIDURIA;;GABA METABOLIC DEFECT;;GAMMA-HYDROXYBUTYRIC ACIDURIA		ALDH5A1
EPILEPSY, FEMALE-RESTRICTED, WITH MENTAL RETARDATION		PCDH19
MENTAL RETARDATION, X-LINKED, SYNDROMIC, CHRISTIANSON TYPE		SLC9A6
POLYMICROGYRIA, BILATERAL PERISYLVIAN
#300423 MENTAL RETARDATION, X-LINKED, SYNDROMIC, HEDERA TYPE; MRXSH;;MENTAL RETARDATION, X-LINKED, WITH EPILEPSY; MRXE		ATP6AP2
#300801 CHROMOSOME XP11.23-P11.22 DUPLICATION SYNDROME
#300842 MCLEOD SYNDROME; MCLDS;;MCLEOD PHENOTYPE;;NEUROACANTHOCYTOSIS, MCLEOD TYPEMCLEOD SYNDROME WITH CHRONIC GRANULOMATOUS DISEASE, INCLUDED		XK
#300848 MENTAL RETARDATION, X-LINKED 89; MRX89		ZNF41
#300868 MULTIPLE CONGENITAL ANOMALIES-HYPOTONIA-SEIZURES SYNDROME 2; MCAHS2		PIGA
#308350 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 1; EIEE1;;INFANTILE SPASM SYNDROME, X-LINKED 1; ISSX1;;WEST SYNDROME, X-LINKED;;OHTAHARA SYNDROME, X-LINKED;;INFANTILE EPILEPTIC-DYSKINETIC ENCEPHALOPATHY;;XMESID		ARX
MYOCLONIC EPILEPSY, PROGRESSIVE
PAINE SYNDROME		MSD
MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC ACIDOSIS, AND STROKE-LIKEEPISODES
MYOCLONIC EPILEPSY ASSOCIATED WITH RAGGED-RED FIBERS
EPILEPSY, CHILDHOOD ABSENCE, 1		ECA1
%600176 PACHYGYRIA WITH MENTAL RETARDATION, SEIZURES, AND ARACHNOID CYSTS;;PACHYGYRIA WITH MENTAL RETARDATION AND SEIZURES
EPILEPSY, IDIOPATHIC GENERALIZED		EGI
EPILEPSY, FAMILIAL ADULT MYOCLONIC, 1		FCMTE1
#601378 CRISPONI SYNDROME;;MUSCLE CONTRACTIONS, TETANOFORM, WITH CHARACTERISTIC FACE, CAMPTODACTYLY,HYPERTHERMIA, AND SUDDEN DEATH
CONVULSIONS, BENIGN FAMILIAL INFANTILE, 1
CONVULSIONS, FAMILIAL INFANTILE, WITH PAROXYSMAL CHOREOATHETOSIS		ICCA ; PRRT2
FEBRILE CONVULSIONS, FAMILIAL, 2		FEB2
%603204 EPILEPSY, NOCTURNAL FRONTAL LOBE, 2; ENFL2
#604233 GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 1; GEFSP1;;GEFS+, TYPE 1; GEFS+1		SCN1B
FEBRILE CONVULSIONS, FAMILIAL, 4		GPR98
#604403 GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 2; GEFSP2;;GEFS+, TYPE 2; GEFS+2FEBRILE SEIZURES, FAMILIAL, 3A, INCLUDED; FEB3A, INCLUDED		SCN1A
MYOCLONIC EPILEPSY, JUVENILE, 2		EJM2
%605013 MICROHYDRANENCEPHALY; MHAC;;HYDRANENCEPHALY AND MICROCEPHALY		MHAC
#605021 MYOCLONIC EPILEPSY, FAMILIAL INFANTILE; FIME;;EIM		TBC1D24
#605751 SEIZURES, BENIGN FAMILIAL INFANTILE, 2; BFIS2;;CONVULSIONS, BENIGN FAMILIAL INFANTILE, 2; BFIC2		PRRT2
#606369 EPILEPTIC ENCEPHALOPATHY, LENNOX-GASTAUT TYPE;;ENCEPHALOPATHY OF CHILDHOOD		MAPK10
#607208 DRAVET SYNDROME;;EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 6; EIEE6;;SEVERE MYOCLONIC EPILEPSY OF INFANCY; SMEI		SCN1A
EPILEPSY WITH GRAND MAL SEIZURES ON AWAKENING
EPILEPSY, JUVENILE ABSENCE
EPILEPSY, CHILDHOOD ABSENCE, 2
#607682 EPILEPSY, IDIOPATHIC GENERALIZED, SUSCEPTIBILITY TO, 9; EIG9EPILEPSY, JUVENILE MYOCLONIC, SUSCEPTIBILITY TO, 6, INCLUDED; EJM6,INCLUDED
%607876 EPILEPSY, FAMILIAL ADULT MYOCLONIC, 2; FAME2;;BENIGN ADULT FAMILIAL MYOCLONIC EPILEPSY 2; BAFME2;;CORTICAL MYOCLONIC TREMOR WITH EPILEPSY, FAMILIAL, 2; FCMTE2;;CORTICAL MYOCLONUS AND EPILEPSY, AUTOSOMAL DOMINANT; ADCME		FCMTE2
EPILEPSY, FAMILIAL TEMPORAL LOBE
EPILEPSY, BENIGN NEONATAL, 3
608278 GROWTH FAILURE, MICROCEPHALY, MENTAL RETARDATION, CATARACTS, LARGEJOINT CONTRACTURES, OSTEOPOROSIS, CORTICAL DYSPLASIA, AND CEREBELLARATROPHY
608809 LEUKOENCEPHALOPATHY, ARTHRITIS, COLITIS, AND HYPOGAMMAGLOBULINEMA;LACH
AMISH INFANTILE EPILEPSY SYNDROME		ST3GAL5
FEBRILE CONVULSIONS, FAMILIAL, 6		FEB6
FEBRILE CONVULSIONS, FAMILIAL, 5		FEB5
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 3		SLC25A22
GENERALIZED EPILEPSY AND PAROXYSMAL DYSKINESIA		KCNMA1
GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 4
CEROID LIPOFUSCINOSIS, NEURONAL, 8, NORTHERN EPILEPSY VARIANT		CLN8
#610951 CEROID LIPOFUSCINOSIS, NEURONAL, 7; CLN7		MFSD8
#611277 GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 3; GEFSP3;;GEFS+, TYPE 3; GEFS+3FEBRILE SEIZURES, FAMILIAL, 8, INCLUDED; FEB8, INCLUDED		GABRG2
MYOCLONIC EPILEPSY, JUVENILE, SUSCEPTIBILITY TO, 4; EJM4
#611556 GLYCOGEN STORAGE DISEASE 0, MUSCLE;;GSD 0B; GSD0B;;MUSCLE GLYCOGEN STORAGE DISEASE 0;;MUSCLE GLYCOGEN SYNTHASE DEFICIENCY		GYS1
FEBRILE CONVULSIONS, FAMILIAL, 9
#611721 COMBINED SAPOSIN DEFICIENCY;;PROSAPOSIN DEFICIENCY; PSAPD;;COMBINED SAP DEFICIENCY		PSAP
#611726 EPILEPSY, PROGRESSIVE MYOCLONIC 3, WITH OR WITHOUT INTRACELLULAR INCLUSIONS;EPM3;;CEROID LIPOFUSCINOSIS, NEURONAL, 14; CLN14		KCTD7
#612164 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 4; EIEE4		STXBP1
#612269 EPILEPSY, CHILDHOOD ABSENCE, SUSCEPTIBILITY TO, 5; ECA5		GABRB3
#612437 EPILEPSY, PROGRESSIVE MYOCLONIC 1B; EPM1B		PRICKLE1
#613060 EPILEPSY, IDIOPATHIC GENERALIZED, SUSCEPTIBILITY TO, 10; EIG10GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 5, SUSCEPTIBILITYTO, INCLUDED; GEFS5, INCLUDED;;GEFS+, TYPE 5, SUSCEPTIBILITY TO, INCLUDED;;GEFS+5, SUSCEPTIBILITY TO, INCLUDED;;GEFSP5, SUSCEPTIBILITY TO, INCLUDED;;EPILEPSY, JUVENILE MYOCLONIC, SUSCEPTIBILITY TO, 7, INCLUDED; EJM7,INCLUDED
613328 ROIFMAN-CHITAYAT SYNDROME;;COMBINED IMMUNODEFICIENCY, FACIAL DYSMORPHISM, OPTIC NERVE ATROPHY,SKELETAL ANOMALIES, AND DEVELOPMENTAL DELAY
%613608 EPILEPSY, FAMILIAL ADULT MYOCLONIC, 3; FAME3;;CORTICAL MYOCLONIC TREMOR WITH EPILEPSY, FAMILIAL, 3; FCMTE3
#613721 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 11; EIEE11		SCN2A
#613722 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 12; EIEE12		PLCB1
#613832 EPILEPSY, PROGRESSIVE MYOCLONIC 5; EPM5		PRICKLE2
#613839 MEGALOBLASTIC ANEMIA DUE TO DIHYDROFOLATE REDUCTASE DEFICIENCY;;DHFR DEFICIENCY		DHFR
#613863 GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 7; GEFSP7;;GEFS+, TYPE 7; GEFS+7FEBRILE SEIZURES, FAMILIAL, 3B, INCLUDED; FEB3B, INCLUDED		SCN9A
#613971 EPILEPSY WITH NEURODEVELOPMENTAL DEFECTS; EPND		GRIN2A
#614018 EPILEPSY, PROGRESSIVE MYOCLONIC 6; EPM6		GOSR2
#614115 CORTICAL MALFORMATIONS, OCCIPITAL; OCCM		LAMC3
#614231 MICROCEPHALY, EPILEPSY, AND DIABETES SYNDROME; MEDS		IER3IP1
%614280 EPILEPSY, JUVENILE MYOCLONIC, SUSCEPTIBILITY TO, 9; EJM9
#614418 FEBRILE SEIZURES, FAMILIAL, 11; FEB11;;CONVULSIONS, FAMILIAL FEBRILE, 11		CPA6
#614457 ICHTHYOSIS, SPASTIC QUADRIPLEGIA, AND MENTAL RETARDATION; ISQMR		ELOVL4
#614487 SPASTIC ATAXIA 5, AUTOSOMAL RECESSIVE; SPAX5		AFG3L2
#614706 CEROID LIPOFUSCINOSIS, NEURONAL, 11; CLN11		GRN
#614847 EPILEPSY, IDIOPATHIC GENERALIZED, SUSCEPTIBILITY TO, 12; EIG12