[Term]
id: INH:0000001
name: Mode of inheritance
namespace: human_inheritance
xref: UMLS:C0242538
xref: UMLS:C0728826

[Term]
id: INH:0000002
name: Autosomal dominant inheritance
namespace: human_inheritance
def: "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
synonym: "Autosomal dominant" EXACT []
synonym: "Autosomal dominant." EXACT []
xref: UMLS:C0443147
is_a: INH:0000001 ! Inheritance

[Term]
id: INH:0000003
name: Autosomal recessive inheritance
namespace: human_inheritance
def: "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
synonym: "Autosomal recessive" EXACT []
synonym: "Autosomal recessive." EXACT []
xref: UMLS:C0441748
is_a: INH:0000001 ! Inheritance

[Term]
id: INH:0000004
name: X-linked inheritance
namespace: human_inheritance
def: "A mode of inheritance that is observed for traits related to a gene encoded on the X chromosome." [HPO:curators]
synonym: "X-linked" EXACT []
xref: UMLS:C0241764
is_a: INH:0000001 ! Inheritance


[Term]
id: INH:0000006
name: Multifactorial
namespace: human_inheritance
xref: UMLS:C1837655
is_a: INH:0000001 ! Inheritance

[Term]
id: INH:0000007
name: Mitochondrial inheritance
namespace: human_inheritance
def: "A mode of inheritance that is observed for traits related to a gene encoded on the mitochondrial genome. Because the mitochondrial genome is almost always maternally inherited, a mitochondrial condition can only be transmitted by females, although the condition can affect both sexes. The proportion of mutant mitochondria can vary (heteroplasmy)." [HPO:curators]
synonym: "Mitochondrial" EXACT []
xref: UMLS:C0026237
xref: UMLS:C0521451
xref: UMLS:C0887941
is_a: INH:0000001 ! Inheritance

[Term]
id: INH:0000008
name: Somatic mutation
namespace: human_inheritance
xref: UMLS:C0544886
is_a: INH:0000001 ! Inheritance

[Term]
id: INH:0000010
name: Somatic mosaicism
namespace: human_inheritance
xref: UMLS:C1866227
is_a: INH:0000001 ! Inheritance

[Term]
id: INH:0000011
name: Y-linked inheritance
namespace: human_inheritance
def: "A mode of inheritance that is observed for traits related to a gene encoded on the Y chromosome." [HPO:curators]
xref: UMLS:C0814045
is_a: INH:0000001 ! Inheritance



[Term]
id: INH:0000017
name: Genetic anticipation
namespace: human_inheritance
alt_id: HP:0003743
xref: UMLS:C0600498
is_a: INH:0000001 ! Inheritance

[Term]
id: INH:0000018
name: Genetic anticipation with paternal anticipation bias
namespace: human_inheritance
alt_id: HP:0003744
xref: UMLS:C1834002
is_a: INH:0000017 ! Genetic anticipation

[Term]
id: INH:0000019
name: Sporadic inheritance
namespace: human_inheritance
alt_id: HP:0003745
xref: UMLS:C0205422
is_a: INH:0000001 ! Inheritance